RIVISTE

• De Gaetano F., Leggio L., Celesti C., Genovese F., Falcone M., Giofrè S.V., Iraci N., Iraci N., Ventura C.A. Study of Host-Guest Interaction and In Vitro Neuroprotective Potential of Cinnamic Acid/Randomly Methylated β-Cyclodextrin Inclusion Complex. International Journal of Molecular Sciences, 2024, 25 (23), art. no. 12778. DOI: 10.3390/ijms252312778
• Schiroli D., Voronov A., Pancrazzi F., Iraci N., Giofrè S. V., Macchi B., Stefanizzi V., Mancuso R., Gabriele B., Pio Mazzeo P., Capaldo L., Della Ca’ N. Direct Access to α,β-Unsaturated γ-Lactams via Palladium-Catalysed Carbonylation of Propargylic Ureas. Advanced Synthesis and Catalysis, 2024, 366, 1-8. DOI: 10.1002/adsc.202401183
• De Gaetano F., Mannino D., Celesti C., Bulzomí M., Iraci N., Giofrè S. V., Esposito E., Paterniti I., Anna Ventura C. Randomly methylated β-cyclodextrin improves water – solubility, cellular protection and mucosa permeability of idebenone. International Journal of Pharmaceutics, 2024, 665, art. no. 124718. DOI: 10.1016/j.ijpharm.2024.124718
• Di Matteo, F., Mancuso, F., Turcio, R., Ciaglia, T., Stagno, C., Di Chio, C., Campiglia, P., Bertamino, A., Giofrè, S.V., Ostacolo, C., Iraci, N. KCNT1 Channel Blockers: A Medicinal Chemistry Perspective, Molecules, 2024, 29 (12), art. no. 2940. DOI: 10.3390/molecules29122940
• Iannazzo, D., Giofrè, S.V., Espro, C., Celesti, C. Graphene-based materials as nanoplatforms for antiviral therapy and prophylaxis. Expert Opinion on Drug Delivery, 2024, DOI: 10.1080/17425247.2024.2364652
• Rossi, A., Stagno, C., Piperno, A., Iraci, N., Panseri, S., Montesi, M., Feizi-Dehnayebi, M., Bassi, G., Di Pietro, M.L., Micale, N. Anticancer activity and morphological analysis of Pt (II) complexes: Their DFT approach, docking simulation, and ADME-Tox profiling. Applied Organometallic Chemistry, 2024, 38 (5), art. no. e7403. DOI: 10.1002/aoc.7403
• Sarà, M., Giofrè, S.V., Abate, S., Trapani, M., Verduci, R., D’Angelo, G., Castriciano, M.A., Romeo, A., Neri, G., Monsù Scolaro, L. Absorption and Fluorescence Emission Investigations on Supramolecular Assemblies of Tetrakis-(4-sulfonatophenyl)porphyrin and Graphene Quantum Dots. Molecules, 2024, 29 (9), art. no. 2015. DOI: 10.3390/molecules29092015
• Akbari, Z., Stagno, C., Iraci, N., Efferth, T., Omer, E.A., Piperno, A., Montazerozohori, M., Feizi-Dehnayebi, M., Micale, N. Biological evaluation, DFT, MEP, HOMO-LUMO analysis and ensemble docking studies of Zn(II) complexes of bidentate and tetradentate Schiff base ligands as antileukemia agents. Journal of Molecular Structure, 2024, 1301, art. no. 137400. DOI: 10.1016/j.molstruc.2023.137400
• Chiacchio, M.A., Campisi, A., Iannazzo, D., Giofrè, S.V., Legnani, L. Design of New Schiff Bases and Their Heavy Metal Ion Complexes for Environmental Applications: A Molecular Dynamics and Density Function Theory Study. International Journal of Molecular Sciences, 2024, 25 (8). DOI: 10.3390/ijms25084159
• Taghizadeh Shool, M., Amiri Rudbari, H., Cuevas-Vicario, J.V., Rodríguez-Rubio, A., Stagno, C., Iraci, N., Efferth, T., Omer, E.A., Schirmeister, T., Blacque, O., Moini, N., Sheibani, E., Micale, N. Investigating the Cytotoxicity of Ru(II) Polypyridyl Complexes by Changing the Electronic Structure of Salicylaldehyde Ligands. Inorganic Chemistry, 2024, 63 (2), pp. 1083-1101. DOI: 10.1021/acs.inorgchem.3c03414
• Romeo, R., Legnani, L., Chiacchio, M.A., Giofré, S.V., Iannazzo, D. Antiviral Compounds to Address Influenza Pandemics: An Update from 2016-2022. Current Medicinal Chemistry, 2024, 31 (18), 2507-2549. DOI: 10.2174/0929867331666230907093501
• Iannazzo, D., Celesti, C., Giofrè, S.V., Ettari, R., Bitto, A. Theranostic Applications of 2D Graphene-Based Materials for Solid Tumors Treatment. Nanomaterials, 2023, 13 (16), art. no. 2380. DOI: 10.3390/nano13162380
• Marsili, G., Acchioni, C., Remoli, A.L., Amatore, D., Sgarbanti, R., De Angelis, M., Orsatti, R., Acchioni, M., Astolfi, A., Iraci, N., Puzelli, S., Facchini, M., Perrotti, E., Cecchetti, V., Sabatini, S., Superti, F., Agamennone, M., Barreca, M.L., Hiscott, J., Nencioni, L., Sgarbanti, M. Identification of Anti-Influenza A Compounds Inhibiting the Viral Non-Structural Protein 1 (NS1) Using a Type I Interferon-Driven Screening Strategy. International Journal of Molecular Sciences, 2023, 24 (13), art. no. 10495. DOI: 10.3390/ijms241310495
• Iannazzo, D., Giofré, S.V. Editorial overview: New synthetic methods: How chemistry change course for a sustainable future. Current Opinion in Green and Sustainable Chemistry, 2023, 41, art. no. 100828. DOI: 10.1016/j.cogsc.2023.100828
• Smeriglio, A., Iraci, N., Denaro, M., Mandalari, G., Giofrè, S.V., Trombetta, D. Synergistic Combination of Citrus Flavanones as Strong Antioxidant and COX-Inhibitor Agent. Antioxidants, 2023, 12 (4), art. no. 972. DOI: 10.3390/antiox12040972
• De Gaetano, F., Scala, A., Celesti, C., Lambertsen Larsen, K., Genovese, F., Bongiorno, C., Leggio, L., Iraci, N., Iraci, N., Mazzaglia, A., Ventura, C.A. Amphiphilic Cyclodextrin Nanoparticles as Delivery System for Idebenone: A Preformulation Study. Molecules, 2023, 28 (7), art. no. 3023. DOI: 10.3390/molecules28073023
• Giofrè, S.V., Celesti, C., Mistretta, G., Tiecco, M. Affinity of deep eutectic solvents with aromatic molecules and aromatic nanostructures in chemical transformations. Current Opinion in Green and Sustainable Chemistry, 2023, 40, art. no. 100779. DOI: 10.1016/j.cogsc.2023.100779
• Di Pietro, M.L., Stagno, C., Efferth, T., Omer, E.A., D’Angelo, V., Germanò, M.P., Cacciola, A., De Gaetano, F., Iraci, N., Micale, N. Antileukemia Activity and Mechanism of Platinum(II)-Based Metal Complexes. Molecules, 2022, 27 (24), art. no. 9000. DOI: 10.3390/molecules27249000
• Iannazzo, D., Celesti, C., Espro, C., Ferlazzo, A., Giofrè, S.V., Scuderi, M., Scalese, S., Gabriele, B., Mancuso, R., Ziccarelli, I., Visalli, G., Di Pietro, A. Orange-Peel-Derived Nanobiochar for Targeted Cancer Therapy. Pharmaceutics, 2022, 14 (10), art. no. 2249. DOI: 10.3390/pharmaceutics14102249
• Musella, S., Carotenuto, L., Iraci, N., Baroli, G., Ciaglia, T., Nappi, P., Basilicata, M.G., Salviati, E., Barrese, V., Vestuto, V., Pignataro, G., Pepe, G., Sommella, E., Di Sarno, V., Manfra, M., Campiglia, P., Gomez-Monterrey, I., Bertamino, A., Taglialatela, M., Ostacolo, C., Miceli, F. Beyond Retigabine: Design, Synthesis, and Pharmacological Characterization of a Potent and Chemically Stable Neuronal Kv7 Channel Activator with Anticonvulsant Activity. Journal of Medicinal Chemistry, 2022, 65 (16), pp. 11340-11364. DOI: 10.1021/acs.jmedchem.2c00911
• Legnani, L., Giofré, S.V., Iannazzo, D., Celesti, C., Veltri, L., Chiacchio, M.A. Chemoselective Oxidation of Isoxazolidines with Ruthenium Tetroxide: A Successful Intertwining of Combined Theoretical and Experimental Data. Molecules, 2022, 27 (17), art. no. 5390.DOI: 10.3390/molecules27175390
• Chiacchio, M.A., Iannazzo, D., Giofrè, S.V., Romeo, R., Legnani, L. Ruthenium tetroxide oxidation of N-methyl-isoxazolidine: Computational mechanistic study. Arabian Journal of Chemistry, 2022, 15 (9), art. no. 104063. DOI: 10.1016/j.arabjc.2022.104063
• Iraci, N., Corsaro, C., Giofrè, S.V., Neri, G., Mezzasalma, A.M., Vacalebre, M., Speciale, A., Saija, A., Cimino, F., Fazio, E. Nanoscale Technologies in the Fight against COVID-19: From Innovative Nanomaterials to Computer-Aided Discovery of Potential Antiviral Plant-Derived Drugs. Biomolecules, 2022, 12 (8), art. no. 1060. DOI: 10.3390/biom12081060
• Celesti, C., Gervasi, T., Cicero, N., Giofrè, S.V., Espro, C., Piperopoulos, E., Gabriele, B., Mancuso, R., Vecchio, G.L., Iannazzo, D. Titanium Surface Modification for Implantable Medical Devices with Anti-Bacterial Adhesion Properties. Materials, 2022, 15 (9), art. no. 3283. DOI: 10.3390/ma15093283
• Carbone, D., Vestuto, V., Ferraro, M.R., Ciaglia, T., Pecoraro, C., Sommella, E., Cascioferro, S., Salviati, E., Novi, S., Tecce, M.F., Amodio, G., Iraci, N., Cirrincione, G., Campiglia, P., Diana, P., Bertamino, A., Parrino, B., Ostacolo, C. Metabolomics-assisted discovery of a new anticancer GLS-1 inhibitor chemotype from a nortopsentin-inspired library: From phenotype screening to target identification. European Journal of Medicinal Chemistry, 2022, 234, art. no. 114233. DOI: 10.1016/j.ejmech.2022.114233
• Giofrè, S.V., Tiecco, M., Ferlazzo, A., Romeo, R., Ciancaleoni, G., Germani, R., Iannazzo, D. Base-Free Copper-Catalyzed Azide-Alkyne Click Cycloadditions (CuAAc) in Natural Deep Eutectic Solvents as Green and Catalytic Reaction Media** European Journal of Organic Chemistry, 2021 (34), 4777-4789. DOI: 10.1002/ejoc.202100698
• Iraci, N., Ostacolo, C., Medina-Peris, A., Ciaglia, T., Novoselov, A.M., Altieri, A., Cabañero, D., Fernandez-Carvajal, A., Campiglia, P., Gomez-Monterrey, I., Bertamino, A., Kurkin, A.V. In Vitro and In Vivo Pharmacological Characterization of a Novel TRPM8 Inhibitor Chemotype Identified by Small-Scale Preclinical Screening. International Journal of Molecular Sciences, 2022, 23 (4), art. no. 2070. DOI: 10.3390/ijms23042070
• Ettari, R., Iraci, N., Di Chio, C., Previti, S., Danzè, M., Zappalà, M. Development of isoquinolinone derivatives as immunoproteasome inhibitors. Bioorganic and Medicinal Chemistry Letters, 2022, 55, art. no. 128478. DOI: 10.1016/j.bmcl.2021.128478
• Speciale, A., Muscarà, C., Molonia, M.S., Cimino, F., Saija, A., Giofrè, S.V. Silibinin as potential tool against SARS-Cov-2: In silico spike receptor-binding domain and main protease molecular docking analysis, and in vitro endothelial protective effects. Phytotherapy Research, 2021, 35 (8), 4616-4625. DOI: 10.1002/ptr.7107
• Sancineto, L., Ostacolo, C., Ortega-Alarcon, D., Jimenez-Alesanco, A., Ceballos-Laita, L., Vega, S., Abian, O., Velazquez-Campoy, A., Moretti, S., Dabrowska, A., Botwina, P., Synowiec, A., Kula-Pacurar, A., Pyrc, K., Iraci, N., Santi, C. L-Arginine Improves Solubility and ANTI SARS-CoV-2 Mpro Activity of Rutin but Not the Antiviral Activity in Cells. Molecules, 2021, 26 (19), art. no. 6062. DOI: 10.3390/molecules26196062.
• Giofrè, S.V., Napoli, E., Iraci, N., Speciale, A., Cimino, F., Muscarà, C., Molonia, M.S., Ruberto, G., Saija, A. Interaction of selected terpenoids with two SARS-CoV-2 key therapeutic targets: An in-silico study through molecular docking and dynamics simulations. Computers in Biology and Medicine, 2021, 134, art. no. 104538. DOI: 10.1016/j.compbiomed.2021.104538
• Scimone, C., Alibrandi, S., Donato, L., Giofrè, S.V., Rao, G., Sidoti, A., D’Angelo, R. Antiretroviral treatment leading to secondary trimethylaminuria: Genetic associations and successful management with riboflavin. Journal of Clinical Pharmacy and Therapeutics, 2021, 46 (2), 304-309. DOI: 10.1111/jcpt.13315
• Romeo, R., Giofrè, S.V., Chiacchio, M.A., Veltri, L., Celesti, C., Iannazzo, D. Synthesis and biological evaluation of 2,3,4-triaryl-1,2,4-oxadiazol-5-ones as p38 mapk inhibitors. Molecules, 2021, 26 (6), art. no. 1745. DOI: 10.3390/molecules26061745
• Giofrè, S.V., Tiecco, M., Celesti, C., Patanè, S., Triolo, C., Gulino, A., Spitaleri, L., Scalese, S., Scuderi, M., Iannazzo, D. Eco-friendly 1,3-dipolar cycloaddition reactions on graphene quantum dots in natural deep eutectic solvent. Nanomaterials, 2020, 10 (12), art. no. 2549, pp. 1-15. DOI: 10.3390/nano10122549
• Ostacolo, C., Miceli, F., Di Sarno, V., Nappi, P., Iraci, N., Soldovieri, M.V., Ciaglia, T., Ambrosino, P., Vestuto, V., Lauritano, A., Musella, S., Pepe, G., Basilicata, M.G., Manfra, M., Perinelli, D.R., Novellino, E., Bertamino, A., Gomez-Monterrey, I.M., Campiglia, P., Taglialatela, M. Synthesis and Pharmacological Characterization of Conformationally Restricted Retigabine Analogues as Novel Neuronal Kv7 Channel Activators. Journal of Medicinal Chemistry, 2020, 63 (1), pp. 163-185. DOI: 10.1021/acs.jmedchem.9b00796.
• Iannazzo, D., Ettari, R., Giofrè, S., Eid, A.H., Bitto, A. Recent advances in nanotherapeutics for multiple myeloma. Cancers, 2020, 12 (11), art. no. 3144, 1-16. DOI: 10.3390/cancers12113144
• Legnani, L., Iannazzo, D., Pistone, A., Celesti, C., Giofrè, S., Romeo, R., Di Pietro, A., Visalli, G., Fresta, M., Bottino, P., Blanco, I., Chiacchio, M.A. Functionalized polyhedral oligosilsesquioxane (POSS) based composites for bone tissue engineering: Synthesis, computational and biological studies. RSC Advances, 2020, 10 (19), 11325-11334. DOI: 10.1039/d0ra01636e
• Pistone, A., Iannazzo, D., Celesti, C., Scolaro, C., Giofré, S.V., Romeo, R., Visco, A. Chitosan/PAMAM/Hydroxyapatite engineered drug release hydrogels with tunable rheological properties. Polymers, 2020, 12 (4), art. no. 0754. DOI: 10.3390/polym12040754
• Giofrè, S.V., Mancuso, R., Araniti, F., Romeo, R., Iannazzo, D., Abenavoli, M.R., Gabriele, B. Microwave-Assisted Synthesis of Sulfurated Heterocycles with Herbicidal Activity: Reaction of 2-Alkynylbenzoic Acids with Lawesson’s Reagent. ChemPlusChem, 2019, 84 (7), 942-950. DOI: 10.1002/cplu.201900316
• Krasowska, D., Iraci, N., Santi, C., Drabowicz, J., Cieslak, M., Kaźmierczak-Barańska, J., Palomba, M., Królewska-Golińska, K., Magiera, J., Sancineto, L. Diselenides and benzisoselenazolones as antiproliferative agents and glutathione-S-transferase inhibitors. Molecules, 2019, 24 (16), art. no. 2914. DOI: 10.3390/molecules24162914.
• Mancuso, R., Ferlazzo, N., De Luca, G., Amuso, R., Piccionello, A.P., Giofrè, S.V., Navarra, M., Gabriele, B. Synthesis, computational evaluation and pharmacological assessment of acetylsalicylic esters as anti-inflammatory agents. Medicinal Chemistry Research, 2019, 28 (3), 292-299. DOI: 10.1007/s00044-018-02284-3
• Albertini, B., Mathieu, V., Iraci, N., Van Woensel, M., Schoubben, A., Donnadio, A., Greco, S.M.L., Ricci, M., Temperini, A., Blasi, P., Wauthoz, N. Tumor Targeting by Peptide-Decorated Gold Nanoparticles. Molecular Pharmaceutics, 2019, 16 (6), pp. 2430-2444. DOI: 10.1021/acs.molpharmaceut.9b00047
• Iannazzo, D., Pistone, A., Celesti, C., Triolo, C., Patané, S., Giofré, S.V., Romeo, R., Ziccarelli, I., Mancuso, R., Gabriele, B., Visalli, G., Facciolà, A., Di Pietro, A. A smart nanovector for cancer targeted drug delivery based on graphene quantum dots. Nanomaterials, 2019, 9 (2), art. no. 282. DOI: 10.3390/nano9020282
• Chiacchio, M.A., Lanza, G., Chiacchio, U., Giofrè, S.V., Romeo, R., Iannazzo, D., Legnani, L. Oxazole-based compounds as anticancer agents. Current Medicinal Chemistry, 2019, 26 (41), 7337-7371. DOI: 10.2174/0929867326666181203130402
• Chiacchio, M.A., Iannazzo, D., Romeo, R., Giofrè, S.V., Legnani, L. Pyridine and pyrimidine derivatives as privileged scaffolds in biologically active agents. Current Medicinal Chemistry, 2019, 26 (40), 7166-7195. DOI: 10.2174/0929867325666180904125400
• Chiacchio, M.A., Legnani, L., Campisi, A., Paola, B., Giuseppe, L., Iannazzo, D., Veltri, L., Giofrè, S., Romeo, R. 1,2,4-Oxadiazole-5-ones as analogues of tamoxifen: Synthesis and biological evaluation. Organic and Biomolecular Chemistry, 2019, 17 (19), 4892-4905. DOI: 10.1039/c9ob00651f
• Romeo, R., Iannazzo, D., Veltri, L., Gabriele, B., Macchi, B., Frezza, C., Marino-Merlo, F., Giofrè, S.V. Pyrimidine 2,4-Diones in the design of new HIV RT inhibitors. Molecules, 2019, 24 (9), art. no. 1718. DOI: 10.3390/molecules24091718
• Zoccali, M., Giuffrida, D., Salafia, F., Giofrè, S.V., Mondello, L. Carotenoids and apocarotenoids determination in intact human blood samples by online supercritical fluid extraction-supercritical fluid chromatography-tandem mass spectrometry. Analytica Chimica Acta, 2018, 1032, 40-47. DOI: 10.1016/j.aca.2018.06.022
• Ambrosino, P., Freri, E., Castellotti, B., Soldovieri, M.V., Mosca, I., Manocchio, L., Gellera, C., Canafoglia, L., Franceschetti, S., Salis, B., Iraci, N., Miceli, F., Ragona, F., Granata, T., DiFrancesco, J.C., Taglialatela, M. Kv7.3 Compound Heterozygous Variants in Early Onset Encephalopathy Reveal Additive Contribution of C-Terminal Residues to PIP2-Dependent K+ Channel Gating. Molecular Neurobiology, 2018, 55 (8), pp. 7009-7024. DOI: 10.1007/s12035-018-0883-5
• Smeriglio, A., Giofrè, S.V., Galati, E.M., Monforte, M.T., Cicero, N., D’Angelo, V., Grassi, G., Circosta, C. Inhibition of aldose reductase activity by Cannabis sativa chemotypes extracts with high content of cannabidiol or cannabigerol. Fitoterapia, 2018, 127, 101-108. DOI: 10.1016/j.fitote.2018.02.002
• Bertamino, A., Iraci, N., Ostacolo, C., Ambrosino, P., Musella, S., Di Sarno, V., Ciaglia, T., Pepe, G., Sala, M., Soldovieri, M.V., Mosca, I., Gonzalez-Rodriguez, S., Fernandez-Carvajal, A., Ferrer-Montiel, A., Novellino, E., Taglialatela, M., Campiglia, P., Gomez-Monterrey, I. Identification of a Potent Tryptophan-Based TRPM8 Antagonist with in Vivo Analgesic Activity. Journal of Medicinal Chemistry, 2018, 61 (14), pp. 6140-6152. DOI: 10.1021/acs.jmedchem.8b00545
• Cammilleri, G., Vazzana, M., Arizza, V., Giunta, F., Vella, A., Lo Dico, G., Giaccone, V., Giofrè, S.V., Giangrosso, G., Cicero, N., Ferrantelli, V. Mercury in fish products: what’s the best for consumers between bluefin tuna and yellowfin tuna? Natural Product Research, 2018, 32 (4), 457-462. DOI: 10.1080/14786419.2017.1309538
• Ambrosino, P., Soldovieri, M.V., Bast, T., Turnpenny, P.D., Uhrig, S., Biskup, S., Döcker, M., Fleck, T., Mosca, I., Manocchio, L., Iraci, N., Taglialatela, M., Lemke, J.R. De novo gain-of-function variants in KCNT2 as a novel cause of developmental and epileptic encephalopathy. Annals of Neurology, 2018, 83 (6), pp. 1198-1204. DOI: 10.1002/ana.25248
• Veltri, L., Giofrè, S.V., Devo, P., Romeo, R., Dobbs, A.P., Gabriele, B. A Palladium Iodide-Catalyzed Oxidative Aminocarbonylation-Heterocyclization Approach to Functionalized Benzimidazoimidazoles. Journal of Organic Chemistry, 2018, 83 (3), 1680-1685. DOI: 10.1021/acs.joc.7b03167
• Barreca, M.L., Iraci, N., Biggi, S., Cecchetti, V., Biasini, E. Pharmacological agents targeting the cellular prion protein. Pathogens, 2018, 7 (1), art. no. 27. DOI: 10.3390/pathogens7010027
• Romeo, R., Chiacchio, M.A., Campisi, A., Monciino, G., Veltri, L., Iannazzo, D., Broggini, G., Giofrè, S.V. Synthesis and biological evaluation of pyrimidine-oxazolidin-2-arylimino hybrid molecules as antibacterial agents. Molecules, 2018, 23 (7), art. no. 1754. DOI: 10.3390/molecules23071754
• Iraci, N., Tabarrini, O., Santi, C., Sancineto, L. NCp7: targeting a multitask protein for next-generation anti-HIV drug development part 2. Noncovalent inhibitors and nucleic acid binders. Drug Discovery Today, 2018, 23 (3), pp. 687-695. DOI: 10.1016/j.drudis.2018.01.022
• Sancineto, L., Iraci, N., Tabarrini, O., Santi, C. NCp7: targeting a multitasking protein for next-generation anti-HIV drug development part 1: covalent inhibitors. Drug Discovery Today, 2018, 23 (2), pp. 260-271. DOI: 10.1016/j.drudis.2017.10.017
• Giuffrida, D., Zoccali, M., Giofrè, S.V., Dugo, P., Mondello, L. Apocarotenoids determination in Capsicum chinense Jacq. cv. Habanero, by supercritical fluid chromatography-triple-quadrupole/mass spectrometry. Food Chemistry, 2017, 231, 316-323. DOI: 10.1016/j.foodchem.2017.03.145
• Alhindi, T., Zhang, Z., Ruelens, P., Coenen, H., Degroote, H., Iraci, N., Geuten, K. Protein interaction evolution from promiscuity to specificity with reduced flexibility in an increasingly complex network. Scientific Reports, 2017, 7, art. no. 44948. DOI: 10.1038/srep44948
• Iannazzo, D., Pistone, A., Ziccarelli, I., Espro, C., Galvagno, S., Giofré, S.V., Romeo, R., Cicero, N., Bua, G.D., Lanza, G., Legnani, L., Chiacchio, M.A. Removal of heavy metal ions from wastewaters using dendrimer-functionalized multi-walled carbon nanotubes. Environmental Science and Pollution Research, 2017, 24 (17), 14735-14747. DOI: 10.1007/s11356-017-9086-2
• Astolfi, A., Felicetti, T., Iraci, N., Manfroni, G., Massari, S., Pietrella, D., Tabarrini, O., Kaatz, G.W., Barreca, M.L., Sabatini, S., Cecchetti, V. Pharmacophore-Based Repositioning of Approved Drugs as Novel Staphylococcus aureus NorA Efflux Pump Inhibitors. Journal of Medicinal Chemistry, 2017, 60 (4), pp. 1598-1604. DOI: 10.1021/acs.jmedchem.6b01439
• Trombetta, D., Smeriglio, A., Marcoccia, D., Giofrè, S., Toscano, G., Mazzotti, F., Giovanazzi, A., Lorenzetti, S. Analytical evaluation and antioxidant properties of some secondary metabolites in northern Italian mono-and multi-varietal extra virgin olive oils (EVOOs) from early and late harvested olives. International Journal of Molecular Sciences, 2017, 18 (4), art. no. 797, 14 p. DOI: 10.3390/ijms18040797
• Iannazzo, D., Pistone, A., Salamò, M., Galvagno, S., Romeo, R., Giofré, S.V., Branca, C., Visalli, G., Di Pietro, A. Graphene quantum dots for cancer targeted drug delivery. International Journal of Pharmaceutics, 2017, 518 (1-2), 185-192. DOI: 10.1016/j.ijpharm.2016.12.060
• Mancuso, R., Pomelli, C.S., Raut, D.S., Marino, N., Giofrè, S.V., Romeo, R., Sartini, S., Chiappe, C., Gabriele, B. Copper-Catalyzed Recyclable Synthesis of (Z)-3-Alkylideneisoindolinones by Cycloisomerization of 2-Alkynylbenzamides in Ionic Liquids. ChemistrySelect, 2017, 2 (3), 894-899. DOI: 10.1002/slct.201601738
• Romeo, R., Giofrè, S.V., Chiacchio, M.A. Synthesis and biological activity of unnatural enediynes. Current Medicinal Chemistry, 2017, 24 (32), 1-57. DOI: 10.2174/0929867324666170425095719
• Giofrè, S.V., Cirmi, S., Mancuso, R., Nicolò, F., Lanza, G., Legnani, L., Campisi, A., Chiacchio, M.A., Navarra, M., Gabriele, B., Romeo, R. Synthesis of spiro[isoindole-1,5′-isoxazolidin]-3(2H)-ones as potential inhibitors of the MDM2-p53 interaction. Beilstein Journal of Organic Chemistry, 2016, 12, 2793-2807. DOI: 10.3762/bjoc.12.278
• Soldovieri, M.V., Ambrosino, P., Mosca, I., De Maria, M., Moretto, E., Miceli, F., Alaimo, A., Iraci, N., Manocchio, L., Medoro, A., Passafaro, M., Taglialatela, M. Early-onset epileptic encephalopathy caused by a reduced sensitivity of Kv7.2 potassium channels to phosphatidylinositol 4,5-bisphosphate. Scientific Reports, 2016, 6, art. no. 38167. DOI: 10.1038/srep38167
• Corsaro, C., Cicero, N., Mallamace, D., Vasi, S., Naccari, C., Salvo, A., Giofrè, S.V., Dugo, G. HR-MAS and NMR towards Foodomics. Food Research International, 2016, 89, 1085-1094. DOI: 10.1016/j.foodres.2016.09.033
• Bertamino, A., Ostacolo, C., Ambrosino, P., Musella, S., Di Sarno, V., Ciaglia, T., Soldovieri, M.V., Iraci, N., Fernandez Carvajal, A., De La Torre-Martinez, R., Ferrer-Montiel, A., Gonzalez Muniz, R., Novellino, E., Taglialatela, M., Campiglia, P., Gomez-Monterrey, I. Tryptamine-Based Derivatives as Transient Receptor Potential Melastatin Type 8 (TRPM8) Channel Modulators. Journal of Medicinal Chemistry, 2016, 59 (5), pp. 2179-2191. DOI: 10.1021/acs.jmedchem.5b01914
• Chiacchio, M.A., Giofrè, S.V., Romeo, R., Romeo, G., Chiacchio, U. Isoxazolidines as biologically active compounds. Current Organic Synthesis, 2016, 13 (5), 726-749. DOI: 10.2174/1570179412666150914195807
• Legnani, L., Toma, L., Caramella, P., Chiacchio, M.A., Giofrè, S., Delso, I., Tejero, T., Merino, P. Computational Mechanistic Study of Thionation of Carbonyl Compounds with Lawesson’s Reagent. Journal of Organic Chemistry, 2016, 81 (17), 7733-7740. DOI: 10.1021/acs.joc.6b01420
• Vadalà, R., Mottese, A.F., Bua, G.D., Salvo, A., Mallamace, D., Corsaro, C., Vasi, S., Giofrè, S.V., Alfa, M., Cicero, N., Dugo, G. Statistical analysis of mineral concentration for the geographic identification of garlic samples from sicily (Italy), Tunisia and Spain. Foods, 2016, 5 (1), art. no. 20, 1-11. DOI: 10.3390/foods5010020
• Chiacchio, U., Broggini, G., Romeo, R., Gazzola, S., Chiacchio, M.A., Giofrè, S.V., Gabriele, B., Mancuso, R., Floresta, G., Zagni, C. Intramolecular oxidative palladium-catalyzed diamination reactions of alkenyl sulfamates: An efficient synthesis of [1,2,5]thiadiazolo-fused piperazinones. RSC Advances, 2016, 6 (62), 57521-57529. DOI: 10.1039/c6ra13141g
• Giofrè, S.V., Romeo, R., Mancuso, R., Cicero, N., Corriero, N., Chiacchio, U., Romeo, G., Gabriele, B. A new microwave-assisted thionation-heterocyclization process leading to benzo[c]thiophene-1(3H)-thione and 1H-isothiochromene-1-thione derivatives. RSC Advances, 2016, 6 (25), 20777-20780. DOI: 10.1039/c6ra01329e
• Giofrè, S.V., Romeo, R., Garozzo, A., Cicero, N., Campisi, A., Lanza, G., Chiacchio, M.A. 5-(3-phosphonated 1H-1,2,3-triazol-4-yl)isoxazolidines: Synthesis, DFT studies and biological properties. Arkivoc, 2015, (7), 253-269.DOI: 10.3998/ark.5550190.p009.353
• Sancineto, L., Mariotti, A., Bagnoli, L., Marini, F., Desantis, J., Iraci, N., Santi, C., Pannecouque, C., Tabarrini, O. Design and Synthesis of DiselenoBisBenzamides (DISeBAs) as Nucleocapsid Protein 7 (NCp7) Inhibitors with anti-HIV Activity. Journal of Medicinal Chemistry, 2015, 58 (24), pp. 9601-9614. DOI: 10.1021/acs.jmedchem.5b01183
• Iannazzo, D., Pistone, A., Visco, A., Galtieri, G., Giofrè, S.V., Romeo, R., Romeo, G., Cappello, S., Bonsignore, M., Denaro, R., Galvagno, S. 1,2,3-Triazole/MWCNT conjugates as filler for gelcoat nanocomposites: New active antibiofouling coatings for marine application. Materials Research Express, 2015, 2 (11), art. no. 115001. DOI: 10.1088/2053-1591/2/11/115001
• Albertini, B., Iraci, N., Schoubben, A., Giovagnoli, S., Ricci, M., Blasi, P., Rossi, C. β-cyclodextrin hinders PLGA plasticization during microparticle manufacturing. Journal of Drug Delivery Science and Technology, 2015, 30, pp. 375-383. DOI: 10.1016/j.jddst.2015.07.022
• Pantò, S., Sciarrone, D., Maimone, M., Ragonese, C., Giofrè, S., Donato, P., Farnetti, S., Mondello, L. Performance evaluation of a versatile multidimensional chromatographic preparative system based on three-dimensional gas chromatography and liquid chromatography-two-dimensional gas chromatography for the collection of volatile constituents. Journal of Chromatography A, 2015, 1417, 96-103. DOI: 10.1016/j.chroma.2015.09.039
• Iraci, N., Stincardini, C., Barreca, M.L., Biasini, E. Decoding the function of the N-terminal tail of the cellular prion protein to inspire novel therapeutic avenues for neurodegenerative diseases. Virus Research, 2015, 207, pp. 62-68. DOI: 10.1016/j.virusres.2014.10.015
• Cicero, N., Corsaro, C., Salvo, A., Vasi, S., Giofré, S.V., Ferrantelli, V., Di Stefano, V., Mallamace, D., Dugo, G. The metabolic profile of lemon juice by proton HR-MAS NMR: The case of the PGI Interdonato Lemon of Messina. Natural Product Research, 2015, 29 (20), 1894-1902. DOI: 10.1080/14786419.2015.1012166
• Astolfi, A., Iraci, N., Sabatini, S., Barreca, M.L., Cecchetti, V. P38α MAPK and Type I inhibitors: Binding site analysis and use of target ensembles in virtual screening. Molecules, 2015, 20 (9), pp. 15842-15861. DOI: 10.3390/molecules200915842
• Sorrenti, V., Vanella, L., Acquaviva, R., Cardile, V., Giofrè, S., Di Giacomo, C. Cyanidin induces apoptosis and differentiation in prostate cancer cells. International Journal of Oncology, 2015, 47 (4), 1303-1310. DOI: 10.3892/ijo.2015.3130
• Araniti, F., Mancuso, R., Lupini, A., Giofrè, S.V., Sunseri, F., Gabriele, B., Abenavoli, M.R. Phytotoxic potential and biological activity of three synthetic coumarin derivatives as new natural-like herbicides. Molecules, 2015, 20 (10), 17883-17902. DOI: 10.3390/molecules201017883
• Astolfi, A., Iraci, N., Manfroni, G., Barreca, M.L., Cecchetti, V. A comprehensive structural overview of p38α MAPK in complex with type I inhibitors. ChemMedChem, 2015, 10 (6), pp. 957-969. DOI: 10.1002/cmdc.201500030
• Giofrè, S.V., Romeo, R., Chiacchio, U., Romeo, G., Chiacchio, M.A. Phosphonated n,o-nucleosides: Synthesis and biological evaluation. Mini-Reviews in Organic Chemistry, 2015, 12 (3), 249-257. DOI: 10.2174/1570193×1203150429104924
• Miroddi, M., Navarra, M., Calapai, F., Mancari, F., Giofrè, S.V., Gangemi, S., Calapai, G. Review of clinical pharmacology of Aloe vera L. in the treatment of psoriasis. Phytotherapy Research, 2015, 29 (5), 648-655. DOI: 10.1002/ptr.5316
• Giofrè, S.V., Romeo, R., Carnovale, C., Mancuso, R., Cirmi, S., Navarra, M., Garozzo, A., Chiacchio, M.A. Synthesis and biological properties of 5-(1H-1,2,3-triazol-4-yl)isoxazolidines: A new class of C-nucleosides. Molecules, 2015, 20 (4), 5260-5275. DOI: 10.3390/molecules20045260
• Romeo, R., Carnovale, C., Giofrè, S.V., Chiacchio, M.A., Garozzo, A., Amata, E., Romeo, G., Chiacchio, U. C-5′-Triazolyl-2′-oxa-3′-aza-4’a-carbanucleosides: Synthesis and biological evaluation. Beilstein Journal of Organic Chemistry, 2015, 11, 328-334. DOI: 10.3762/bjoc.11.38
• Macchi, B., Romeo, G., Chiacchio, U., Frezza, C., Giofrè, S.V., Marino-Merlo, F., Mastino, A. Phosphonated nucleoside analogues as antiviral agents. Topics in Medicinal Chemistry, 2015, 15, 53-92. DOI: 10.1007/7355_2013_28
• Rescifina, A., Zagni, C., Mineo, P.G., Giofrè, S.V., Chiacchio, U., Tommasone, S., Talotta, C., Gaeta, C., Neri, P. DNA recognition with polycyclic-aromatic-hydrocarbon-presenting calixarene conjugates. European Journal of Organic Chemistry, 2014, (34), 7605-7613. DOI: 10.1002/ejoc.201403050
• Sancineto, L., Iraci, N., Barreca, M.L., Massari, S., Manfroni, G., Corazza, G., Cecchetti, V., Marcello, A., Daelemans, D., Pannecouque, C., Tabarrini, O. Exploiting the anti-HIV 6-desfluoroquinolones to design multiple ligands. Bioorganic and Medicinal Chemistry, 2014, 22 (17), pp. 4658-4666. DOI: 10.1016/j.bmc.2014.07.018
• Trombetta, D., Giofre, S.V., Tomaino, A., Raciti, R., Saija, A., Cristani, M., Romeo, R., Siracusa, L., Ruberto, G. Selective COX-2 inhibitory properties of dihydrostilbenes from liquorice leaves-in vitro assays and structure/activity relationship study. Natural Product Communications, 2014, 9 (12), 1761-1764. DOI: 10.1177/1934578×1400901226
• Manfroni, G., Manvar, D., Barreca, M.L., Kaushik-Basu, N., Leyssen, P., Paeshuyse, J., Cannalire, R., Iraci, N., Basu, A., Chudaev, M., Zamperini, C., Dreassi, E., Sabatini, S., Tabarrini, O., Neyts, J., Cecchetti, V. New pyrazolobenzothiazine derivatives as hepatitis C virus NS5B polymerase palm site I inhibitors. Journal of Medicinal Chemistry, 57 2014, (8), pp. 3247-3262. DOI: 10.1021/jm401688h
• Romeo, R., Carnovale, C., Giofrè, S.V., Monciino, G., Chiacchio, M.A., Sanfilippo, C., Macchi, B. Enantiomerically pure phosphonated carbocyclic 2′-Oxa-3′-azanucleosides: Synthesis and biological evaluation. Molecules, 2014, 19 (9), 14406-14416. DOI: 10.3390/molecules190914406
• Manfroni, G., Cannalire, R., Barreca, M.L., Kaushik-Basu, N., Leyssen, P., Winquist, J., Iraci, N., Manvar, D., Paeshuyse, J., Guhamazumder, R., Basu, A., Sabatini, S., Tabarrini, O., Danielson, U.H., Neyts, J., Cecchetti, V. The Versatile Nature of the 6-Aminoquinolone Scaffold: Identification of Submicromolar Hepatitis C Virus NS5B Inhibitors. Journal of Medicinal Chemistry, 2014, 57 (5), pp. 1952-1963. DOI: 10.1021/jm401362f
• Romeo, R., Giofrè, S.V., Carnovale, C., Chiacchio, M.A., Campisi, A., Mancuso, R., Cirmi, S., Navarra, M. Synthesis and Biological Activity of Triazole-Appended N,O-Nucleosides. European Journal of Organic Chemistry, 2014, (25), 5442-5447. DOI: 10.1002/ejoc.201402106
• Sgarbanti, M., Marsili, G., Remoli, A.L., Stellacci, E., Mai, A., Rotili, D., Perrotti, E., Acchioni, C., Orsatti, R., Iraci, N., Ferrari, M., Borsetti, A., Hiscott, J., Battistini, A. IκB kinase ε targets interferon regulatory factor 1 in activated T lymphocytes. Molecular and Cellular Biology, 2014, 34 (6), pp. 1054-1065. DOI: 10.1128/MCB.01161-13
• Cimino, S., Favilla, V., Russo, G.I., Galvano, F., Li Volti, G., Barbagallo, I., Giofrè, S.V., D’Orazio, N., Di Rosa, A., Madonia, M., Morgia, G. Oxidative stress and body composition in prostate cancer and benign prostatic hyperplasia patients. Anticancer Research, 2014, 34 (9), 5051-5056.
• Barreca, M.L., Iraci, N., Manfroni, G., Gaetani, R., Guercini, C., Sabatini, S., Tabarrini, O., Cecchetti, V. Accounting for target flexibility and water molecules by docking to ensembles of target structures: The HCV NS5B palm site I inhibitors case study. Journal of Chemical Information and Modeling, 2014, 54 (2), pp. 481-497. DOI: 10.1021/ci400367m
• Bisignano, C., Filocamo, A., Ginestra, G., Giofre’, S.V., Navarra, M., Romeo, R., Mandalari, G. 3,4-DHPEA-EA from Olea Europaea L. is effective against standard and clinical isolates of Staphylococcus sp. Annals of Clinical Microbiology and Antimicrobials, 2014, 13 (1), art. no. 24. DOI: 10.1186/1476-0711-13-24
• Romeo, R., Navarra, M., Giofrè, S.V., Carnovale, C., Cirmi, S., Lanza, G., Chiacchio, M.A. Synthesis and biological activity of new arenediyne-linked isoxazolidines. Bioorganic and Medicinal Chemistry, 2014, 22 (13), 3379-3385. DOI: 10.1016/j.bmc.2014.04.047
• Mancuso, R., Ziccarelli, I., Armentano, D., Marino, N., Giofrè, S.V., Gabriele, B. Divergent palladium iodide catalyzed multicomponent carbonylative approaches to functionalized isoindolinone and isobenzofuranimine derivatives. Journal of Organic Chemistry, 2014, 79 (8), 3506-3518. DOI: 10.1021/jo500281h
• Giofrè, S.V., Romeo, R., Chiacchio, M.A. Phosphonated isoxazolidinyl nucleosides, a new class of modified nucleosides. EuroMediterranean Biomedical Journal, 2014, 9 (8), art. no. 7, 45-55. DOI: 10.3269/1970-5492.2014.9.7
• Oliverio, M., Nardi, M., Costanzo, P., Cariati, L., Cravotto, G., Giofrè, S.V., Procopio, A. Non-conventional methodologies in the synthesis of 1-indanones. Molecules, 2014, 19 (5), 5599-5610. DOI: 10.3390/molecules19055599
• Romeo, R., Giofrè, S.V., Carnovale, C., Campisi, A., Parenti, R., Bandini, L., Chiacchio, M.A. Synthesis and biological evaluation of 3-hydroxymethyl-5-(1H-1,2,3-triazol) isoxazolidines. Bioorganic and Medicinal Chemistry, 2013, 21 (24), 7929-7937. DOI: 10.1016/j.bmc.2013.10.001
• Sabatini, S., Gosetto, F., Iraci, N., Barreca, M.L., Massari, S., Sancineto, L., Manfroni, G., Tabarrini, O., Dimovska, M., Kaatz, G.W., Cecchetti, V. Re-evolution of the 2-phenylquinolines: Ligand-based design, synthesis, and biological evaluation of a potent new class of staphylococcus aureus NorA efflux pump inhibitors to combat antimicrobial resistance. Journal of Medicinal Chemistry, 2013, 56 (12), pp. 4975-4989. DOI: 10.1021/jm400262a
• Romeo, R., Giofrè, S.V., Garozzo, A., Bisignano, B., Corsaro, A., Chiacchio, M.A. Synthesis and biological evaluation of furopyrimidine N,O-nucleosides. Bioorganic and Medicinal Chemistry, 2013, 21 (18), 5688-5693. DOI: 10.1016/j.bmc.2013.07.031
• Sancineto, L., Massari, S., Iraci, N., Tabarrini, O. From small to powerful: The fragments universe and its ‘chem-appeal’. Current Medicinal Chemistry, 2013, 20 (11), pp. 1355-1381. DOI: 10.2174/09298673113209990111
• Chiacchio, U., Corsaro, A., Giofrè, S., Romeo, G. Isoxazolidinyl Nucleosides. Chemical Synthesis of Nucleoside Analogues, 2013, 781-818. DOI: 10.1002/9781118498088.ch17
• Barreca, M.L., Manfroni, G., Leyssen, P., Winquist, J., Kaushik-Basu, N., Paeshuyse, J., Krishnan, R., Iraci, N., Sabatini, S., Tabarrini, O., Basu, A., Danielson, U.H., Neyts, J., Cecchetti, V. Structure-based discovery of pyrazolobenzothiazine derivatives as inhibitors of hepatitis C virus replication. Journal of Medicinal Chemistry, 2013, 56 (6), pp. 2270-2282. DOI: 10.1021/jm301643a
• Lanza, G., Chiacchio, M.A., Giofrè, S.V., Romeo, R., Merino, P. The high selectivity of the Cp₂ZrHCl reducing agent for imides: A combined experimental and theoretical study on γ-lactam and isoxazolidinone derivatives. European Journal of Organic Chemistry, 2013, (1), 95-104. DOI: 10.1002/ejoc.201201186
• Sancineto, L., Iraci, N., Massari, S., Attanasio, V., Corazza, G., Barreca, M.L., Sabatini, S., Manfroni, G., Avanzi, N.R., Cecchetti, V., Pannecouque, C., Marcello, A., Tabarrini, O. Computer-aided design, synthesis and validation of 2-phenylquinazolinone fragments as CDK9 inhibitors with anti-HIV-1 tat-mediated transcription activity. ChemMedChem, 2013, 8 (12), pp. 1941-1953. DOI: 10.1002/cmdc.201300287
• Romeo, R., Carnovale, C., Giofrè, S.V., Romeo, G., MacChi, B., Frezza, C., Marino-Merlo, F., Pistarà, V., Chiacchio, U. Truncated phosphonated C-1′-branched N,O-nucleosides: A new class of antiviral agents. Bioorganic and Medicinal Chemistry, 2012, 20 (11), 3652-3657. DOI: 10.1016/j.bmc.2012.03.047
• Shytaj, I.L., Norelli, S., Chirullo, B., Della Corte, A., Collins, M., Yalley-Ogunro, J., Greenhouse, J., Iraci, N., Acosta, E.P., Barreca, M.L., Lewis, M.G., Savarino, A. A highly intensified ART regimen induces long-term viral suppression and restriction of the viral reservoir in a simian AIDS model. PLoS Pathogens, 2012, 8 (6), art. no. e1002774. DOI: 10.1371/journal.ppat.1002774
• Romeo, R., Giofrè, S.V., Macchi, B., Balestrieri, E., Mastino, A., Merino, P., Carnovale, C., Romeo, G., Chiacchio, U. Truncated Reverse Isoxazolidinyl Nucleosides: A New Class of Allosteric HIV-1 Reverse Transcriptase Inhibitors. ChemMedChem, 2012, 7 (4), 565-569. DOI: 10.1002/cmdc.201200022
• Sabatini, S., Gosetto, F., Serritella, S., Manfroni, G., Tabarrini, O., Iraci, N., Brincat, J.P., Carosati, E., Villarini, M., Kaatz, G.W., Cecchetti, V. Pyrazolo[4,3-c ][1,2]benzothiazines 5,5-dioxide: A promising new class of staphylococcus aureus NorA efflux pump inhibitors. Journal of Medicinal Chemistry, 2012, 55 (7), pp. 3568-3572. DOI: 10.1021/jm201446h
• Manfroni, G., Meschini, F., Barreca, M.L., Leyssen, P., Samuele, A., Iraci, N., Sabatini, S., Massari, S., Maga, G., Neyts, J., Cecchetti, V. Pyridobenzothiazole derivatives as new chemotype targeting the HCV NS5B polymerase. Bioorganic and Medicinal Chemistry, 2012, 20 (2), pp. 866-876. DOI: 10.1016/j.bmc.2011.11.061
• Piperno, A., Carnovale, C., Giofrè, S.V., Iannazzo, D. Hydrozirconation of four-, five-, six- and seven-membered N-alkoxycarbonyl lactams to lactamols. Tetrahedron Letters, 2011, 52 (51), 6880-6882. DOI: 10.1016/j.tetlet.2011.10.006
• Barreca, M.L., Iraci, N., Manfroni, G., Cecchetti, V. Allosteric inhibition of the hepatitis C virus NS5B polymerase: In silico strategies for drug discovery and development. Future Medicinal Chemistry, 2011, 3 (8), pp. 1027-1055. DOI: 10.4155/fmc.11.53
• Romeo, R., Giofrè, S.V., Iaria, D., Sciortino, M.T., Ronsisvalle, S., Chiacchio, M.A., Scala, A. Synthesis of 5-alkynyl isoxazolidinyl nucleosides. European Journal of Organic Chemistry, 2011, (28), 5690-5695. DOI: 10.1002/ejoc.201100767
• Ettari, R., Zappalà, M., Micale, N., Grazioso, G., Giofrè, S., Schirmeister, T., Grasso, S. Peptidomimetics containing a vinyl ketone warhead as falcipain-2 inhibitors. European Journal of Medicinal Chemistry, 2011, 46 (6), 2058-2065. DOI: 10.1016/j.ejmech.2011.02.058
• Balestrieri, E., Pizzimenti, F., Ferlazzo, A., Giofrè, S.V., Iannazzo, D., Piperno, A., Romeo, R., Chiacchio, M.A., Mastino, A., Macchi, B. Antiviral activity of seed extract from Citrus bergamia towards human retroviruses. Bioorganic and Medicinal Chemistry, 2011, 19 (6), 2084-2089. DOI: 10.1016/j.bmc.2011.01.024
• Iannazzo, D., Carnovale, C., Giofrè, S.V., Ettari, R., Romeo, G., Romeo, R., Lanza, G., Chiacchio, U. Formation of 3-aminofuran-2-(5 H)-ones and 3-amino-1 H -pyrrole-2,5-diones by rearrangement of isoxazolidines. Synlett, 2011, (2), art. no. G34710ST, 245-248. DOI: 10.1055/s-0030-1259308
• Iannazzo, D., Brunaccini, E., Giofrè, S.V., Piperno, A., Romeo, G., Ronsisvalle, S., Chiacchio, M.A., Lanza, G., Chiacchio, U. Competitive formation of β-enaminones and 3-amino-2(5H)-furanones from the isoxazolidine system: A combined synthetic and quantum chemical study. European Journal of Organic Chemistry, 2010, (30), 5897-5905. DOI: 10.1002/ejoc.201000579
• Lewis, M.G., Norelli, S., Collins, M., Barreca, M.L., Iraci, N., Chirullo, B., Yalley-Ogunro, J., Greenhouse, J., Titti, F., Garaci, E., Savarino, A. Response of a simian immunodeficiency virus (SIVmac251) to raltegravir: A basis for a new treatment for simian AIDS and an animal model for studying lentiviral persistence during antiretroviral therapy. Retrovirology, 2010, 7, art. no. 21. DOI: 10.1186/1742-4690-7-21
• Monforte, A.-M., Logoteta, P., Luca, L.D., Iraci, N., Ferro, S., Maga, G., De Clercq, E., Pannecouque, C., Chimirri, A. Novel 1,3-dihydro-benzimidazol-2-ones and their analogues as potent non-nucleoside HIV-1 reverse transcriptase inhibitors. Bioorganic and Medicinal Chemistry, 2010, 18 (4), pp. 1702-1710. DOI: 10.1016/j.bmc.2009.12.059
• Piperno, A., Giofrè, S.V., Iannazzo, D., Romeo, R., Romeo, G., Chiacchio, U., Rescifina, A., Piotrowska, D.G. Synthesis of C-4′Truncated Phosphonated Carbocyclic 2′-Oxa-3′-azanucleosides as Antiviral Agents. Journal of Organic Chemistry, 2010, 75 (9), 2798-2805. DOI: 10.1021/jo902485m
• Romeo, G., Giofré, S.V., Piperno, A., Romeo, R., Chiacchiob, M.A. Synthesis of N,O-homonucleosides with high conformational freedom. Arkivoc, 2009 (8), 168-176. DOI: 10.3998/ark.5550190.0010.814
• Barreca, M.L., Iraci, N., De Luca, L., Chimirri, A. Induced-fit docking approach provides insight into the binding mode and mechanism of action of HIV-1 integrase inhibitors. ChemMedChem, 2009, 4 (9), pp. 1446-1456. DOI: 10.1002/cmdc.200900166
• Monforte, A.-M., Logoteta, P., Ferro, S., Luca, L.D., Iraci, N., Maga, G., Clercq, E.D., Pannecouque, C., Chimirri, A. Design, synthesis, and structure-activity relationships of 1,3-dihydrobenzimidazol-2-one analogues as anti-HIV agents. Bioorganic and Medicinal Chemistry, 2009, 17 (16), pp. 5962-5967. DOI: 10.1016/j.bmc.2009.06.068
• De Luca, L., Barreca, M.L., Ferro, S., Christ, F., Iraci, N., Gitto, R., Monforte, A.M., Debyser, Z., Chimirri, A. Pharmacophore-based discovery of small-molecule inhibitors of protein-protein interactions between HIV-1 integrase and cellular cofactor LEDGF/p75. ChemMedChem, 2009, 4 (8), pp. 1311-1316. DOI: 10.1002/cmdc.200900070
• Ferro, S., De Luca, L., Barreca, M.L., Iraci, N., De Grazia, S., Christ, F., Witvrouw, M., Debyser, Z., Chimirri, A. Docking studies on a new human immunodeficiency virus integrase-Mg-DNA complex: phenyl ring exploration and synthesis of 1H-benzylindole derivatives through fluorine substitutions. Journal of medicinal chemistry, 2009, 52 (2), pp. 569-573. DOI: 10.1021/jm8009266
• Stancanelli, R., Crupi, V., De Luca, L., Ficarra, P., Ficarra, R., Gitto, R., Guardo, M., Iraci, N., Majolino, D., Tommasini, S., Venuti, V. Improvement of water solubility of non-competitive AMPA receptor antagonists by complexation with β-cyclodextrin. Bioorganic and Medicinal Chemistry, 2008, 16 (18), pp. 8706-8712. DOI: 10.1016/j.bmc.2008.07.085
• Monforte, A.-M., Rao, A., Logoteta, P., Ferro, S., De Luca, L., Barreca, M.L., Iraci, N., Maga, G., De Clercq, E., Pannecouque, C., Chimirri, A. Novel N1-substituted 1,3-dihydro-2H-benzimidazol-2-ones as potent non-nucleoside reverse transcriptase inhibitors. Bioorganic and Medicinal Chemistry, 2008, 16 (15), pp. 7429-7435. DOI: 10.1016/j.bmc.2008.06.012
• De Luca, L., Barreca, M.L., Ferro, S., Iraci, N., Michiels, M., Christ, F., Debyser, Z., Witvrouw, M., Chimirri, A. A refined pharmacophore model for HIV-1 integrase inhibitors: Optimization of potency in the 1H-benzylindole series. Bioorganic and Medicinal Chemistry Letters, 2008, 18 (9), pp. 2891-2895. DOI: 10.1016/j.bmcl.2008.03.089
• Piperno, A., Chiacchio, U., Iannazzo, D., Giofrè, S.V., Romeo, G., Romeo, R. First example of direct RuO4- catalyzed oxidation of isoxazolidines to 3-isoxazolidones. Journal of Organic Chemistry, 2007, 72 (10), 3958-3960. DOI: 10.1021/jo070211n
• Barreca, M.L., Ortuso, F., Iraci, N., De Luca, L., Alcaro, S., Chimirri, A. Tn5 transposase as a useful platform to simulate HIV-1 integrase inhibitor binding mode. Biochemical and Biophysical Research Communications, 2007, 363 (3), pp. 554-560. DOI: 10.1016/j.bbrc.2007.08.199
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